Ganoderic Acid D Protects Human Amniotic Mesenchymal Stem Cells against Oxidative Stress-Induced Senescence through the PERK/NRF2 Signaling Pathway

Figure 7

Schematic diagram showing the proposed antisenescence mechanism of GA-D in hAMSCs. According to this model, GA-D activating PERK results in intranuclear transfer of NRF2, which then upregulates the expression of PRDX3 and inhibits ROS. Additionally, the activation of PERK also inhibits ERS by triggering UPR, overall resulting in inhibition of senescence.