Role of Prefrontal Cortex on Recognition Memory Deficits in Rats following 6-OHDA-Induced Locus Coeruleus Lesion
6-OHDA-induced LC lesion promotes mitochondrial membrane disruption in the LC of rats. Effect of 6-OHDA-induced LC lesion on (a) ROS production, (b) cell membrane damage, and (c) mitochondrial membrane potential in the LC slices at 15 days after administration. Data are expressed as the of 4-5 animals per group. (Student’s -test). Correlation between the % of time spent in the novel object during the long-term memory test and the (d) ROS production, (e) PI incorporation, and (f) mitochondrial membrane potential in the LC. Each dot represents one pair comprising both analyses from the same animal.
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