Role of Prefrontal Cortex on Recognition Memory Deficits in Rats following 6-OHDA-Induced Locus Coeruleus Lesion
6-OHDA-induced LC lesion promotes oxidative stress, mitochondrial membrane disruption, and cell membrane damage in the PFC of rats. Effect of 6-OHDA-induced LC lesion on (a) ROS production, (b) cell membrane damage, and (c) mitochondrial membrane potential in the PFC slices at 15 days after administration. Data are expressed as the of 4-5 animals per group. (Student’s -test). Correlation between the % of time spent in the novel object during the long-term memory test and the (d) ROS production, (e) PI incorporation, and (f) mitochondrial membrane potential in the PFC. Each dot represents one pair comprising both analysis from the same animal.
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