Research Article
Vanillic Acid Alleviates Acute Myocardial Hypoxia/Reoxygenation Injury by Inhibiting Oxidative Stress
Figure 5
Vanillic acid (VA) preconditioning limited mPTP opening in response to hypoxia/reoxygenation (H/R) in H9c2 cells, while AMPKα2-siRNA attenuates this effect. (a) After the addition of 200 μM CaCl2, the absorbance value at A520 was monitored over 20 min to reflect the opening of mitochondrial permeability transition pore (mPTP). (b) Changes in absorbance values at 520 nm/min (ΔODmin−1) were used to express the extent of mPTP opening (). Data are expressed as the , . vs. control group; vs. H/R group; ▲ vs. VA+H/R group.
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