|
Diseases | Effects of H2 | Reference |
|
Respiratory system | Regulates IL-2, IL-7, IL-10, and TNF-α | [66] |
Increases surfactant proteins | [11] |
Reverses EMT and increases E-cadherin | [68] |
Cardiovascular system | Suppresses macrophage infiltration, TNF-α expression, and vascular aging | [88] |
Inhibits cardiomyocyte apoptosis | [39, 40] |
Decreases MDA, 8-OHdG, and IL-1β | [92, 93] |
Nervous system | Reduces loss of dopaminergic neurons and improves nigrostriatal degeneration | [74, 75] |
Reduces neurological deficits and endothelial cell injury | [83, 84] |
Digestive system | Induces HO-1 and Sirt1 expression | [98] |
Activates the A2A receptor-mediated PI3K-Akt pathway | [99] |
Inhibits bile acid oxidation | [114] |
Reproductive system | Inhibits cell proliferation and improves SOD | [130] |
Improves serum levels of anti-Müllerian hormone | [133] |
Improves serum testosterone level | [135] |
Urinary system | Increases Il-4 and Il-13 and promotes macrophage polarization to the M2 type | [140] |
Activates the Keap1/Nrf2 signaling pathway | [145] |
Prevents HK-2 cells from undergoing EMT | |
Motor system | Reduces blood lactate levels | [47] |
Suppresses serum 8-OHdG levels | [154] |
Sensory system | Reduces wound area and levels of proinflammatory cytokines | [159] |
Improves auditory brainstem response | [161] |
Metabolic syndrome | Decreases LDL and increases high-density lipoprotein | [148] |
Decreases glucose and insulin levels | [149] |
Stimulates energy metabolism | [152] |
Cancer | Controls cancer progression and improves quality-of-life | [140] |
Reduces proportion of terminal PD-1+ CD8+ T cells | [37] |
|