The Gut Microbiota and Oxidative Stress in Autism Spectrum Disorders (ASD)

Figure 1

The connections among oxidative stress, mitochondrial dysfunction, and dysfunction of GIT in autistic children. The dysfunction of GIT in autistic children is related to mitochondrial dysfunction, and there is an interaction between oxidative stress and mitochondrial dysfunction. SCFAs, metabolites of the GIT microbiota, not only participate in the reaction process of oxidative stress but also can result in mitochondrial hyperactivity and further make mitochondria allergic to the oxidative stress.