Pleiotropic Properties of Amphiphilic Dihydropyridines, Dihydropyridones, and Aminovinylcarbonyl Compounds

Table 1

Structure, cytotoxicity, and calculated basal toxicity of 1,4-dihydropyridines containing cationic moieties.

Comp.

Cat^+

HT-1080

MH-22A

NIH3T3

Ref.

(CV); (μg/ml)

(MTT); (μg/ml)

(CV); (μg/ml)

(MTT); (μg/ml)

(NR); (μg/ml)

(mg/kg)

1

Py

C2H5

Ph

C2H5

Br

>2000

[29]

2

Py-Me-4

C2H5

Ph

C2H5

Br

>740

>3360

[30]

3

Py-NH2-4

C2H5

Ph

C2H5

Br

nt

nt

>740

>3360

Suppl.

4

Py-NMe2-4

C2H5

Ph

C2H5

Br

nt

nt

>3500

Suppl.

5

Py-Me-3

C2H5

Ph

C2H5

Br

nt

>740

nt

>3360

Suppl.

6

Py

C2H5

C6H4-CF3-2

C2H5

Br

>2000

[20]

7

Py

C2H4OC3H7

C6H4-OCHF2-2

C2H4OC3H7

Br

>2000

[20]

8

Py

C2H5

COOCH3

C2H5

I

>2000

[20]

9

N-Me-morph

CH3

C6H4-OCHF2-2

CH3

ClO4

>2000

[31]

10

Py

C12H25

Ph

C12H25

Br

1482

[13, 28]

11

Py

C12H25

Ph

C12H25

BF4

1053

Suppl

12

Py-Me-4

C12H25

Ph

C12H25

Br

1431

[13]

13

Py-NMe2-4

C12H25

Ph

C12H25

Br

1706

[13]

14

Py-C(=O)CH3-3

C12H25

Ph

C12H25

Br

4040

[13]

15

N-Me-morph

C12H25

Ph

C12H25

ClO4

979

[13]

16

Pyr

C12H25

Ph

C12H25

Br

>2000

[13]

17

NMe2CyHex

C12H25

Ph

C12H25

Br

1274

Suppl

18

Py

C12H25

C6H4-OH-4

C12H25

Br

1479

Suppl

19

Py-CH3-4

C12H25

C6H4-OH-4

C12H25

Br

1087

Suppl

20

N-Me2C12H25

C12H25

Ph

C12H25

Br

836

Suppl

21

Py-CF3-4

C12H25

Ph

C12H25

Br

619

[32]

22

Py

C12H24CF3

Ph

C12H24CF3

ClO4

771

[32]

23

Py

C12H25

Ph

(CH2)4(CF2)7CF3

Br

3448

Suppl

24

Py

(CH2)4(CF2)7CF3

Ph

(CH2)4(CF2)7CF3

Br

>2000

Suppl

25

Py

(CH2)11(CF2)7CF3

Ph

(CH2)11(CF2)7CF3

Br

>2000

Suppl

26

“Dimeric” form of comp. 10

Br

5164

Suppl

27

Oxidated form of comp. 10

ClO4

3946

[14]

nt: not tested; : not detected.