Pleiotropic Properties of Amphiphilic Dihydropyridines, Dihydropyridones, and Aminovinylcarbonyl Compounds

Table 2

Structure, cytotoxicity, and calculated basal toxicity of 3,4-dihydro-2(1H)-pyridones containing cationic moiety.

Comp.

Cat^+

HT-1080

MH-22A

NIH3T3

Ref.

(CV) (μg/ml)

(MTT) (μg/ml)

(CV); (μg/ml)

(MTT); (μg/ml)

(NR); (μg/ml)

(mg/kg)

28

H

Py

CH3

C6H4-OCHF2-2

Br

>100

>2000

Suppl

29

PhCH2

Py

CH3

H

Br

>2000

Suppl

30

H

PPh3

(CH2)4(CF2)7CF3

Ph

Br

1779

[33]

31

H

Py

(CH2)4(CF2)7CF3

Ph

Br

604

[33]

32

H

Py

(CH2)4(CF2)7CF3

Ph

ClO4

618

Suppl

33

H

N-Me2C12H25

CH3

Ph

Br

269

Suppl

34

H

N-Me2C12H25

C12H25

Ph

Br

346

Suppl

35

H

N-Me2C12H25

(CH2)4(CF2)7CF3

Ph

Br

898

Suppl

36

H

N-Me2C12H25

CH3

H

Br

831

Suppl

37

H

N-Me2C12H25

C12H25

H

Br

369

Suppl

38

H

N-Me2C12H25

(CH2)4(CF2)7CF3

H

Br

553

Suppl

: not detected.