Pleiotropic Properties of Amphiphilic Dihydropyridines, Dihydropyridones, and Aminovinylcarbonyl Compounds

Table 3

Structures, cytotoxicity, and calculated toxicity of 2-amino-3-alkoxycarbonylalkylammonium halides.

Comp.	Cat^+			HT-1080		MH-22A		NIH3T3		Ref.
				(CV) (μg/ml)	(MTT) (μg/ml)	(CV) (μg/ml)	(MTT) (μg/ml)	(NR) (μg/ml)	(mg/kg)
39	N-Me2CyHex	C16H33	Cl						97	Suppl
40	N-Me(CH2)4	C16H33	Cl	<1	<1		<1		312	Suppl
41	N-Me2(CH2)2NMe2	C16H33	Cl						286	Suppl
42	N-Me(CH2)2N(CH2)2Me	C16H33	Cl						237	Suppl
43	N-Me2C6H13	C16H33	Cl						538	Suppl
44	N-Me2C12H25	C16H33	Br						697	Suppl
45	N-Me2C12H25	C16H33	Cl	nt	nt	nt	nt		573	Suppl
46	N-Me2C12H25	C16H33	I	nt	nt	nt	nt		637	Suppl
47	Py	C12H25	I		nt		nt		403	Suppl
48	N-Me2C12H25	C10H21	Cl		nt		nt		485	Suppl

nt: not tested.