The Inhibition of P-Selectin Reduced Severe Acute Lung Injury in Immunocompromised Mice

Figure 6

Knockout of p-selectin alleviate acute lung injury in ICH mice. (a) The expression of serum P-selectin in mice; (b–c) the expression of serum P-selectin in P-selectin knockout mice detected by Elisa assay and RT-PCR; (d) representative HE sections of the lung tissues (magnification, ×400); (e) lung histology scores; (f) The Wet/Dry weight ratio of lung tissues; (g) the survival curve of mice; (h–i) peripheral blood circulation leukocyte and platelet counts; (j) immunofluorescence sections of mice lung tissue. Values are expressed as mean ± SEM. vs control; ^& vs Normal group; ^# vs P-KO group; ^※ vs KPN + ICH group(five mice per group).

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