Immunosuppressant-Induced Oxidative Stress and Iron: A Paradigm Shift from Systemic to Intrahepatic Abnormalities

Figure 7

Microphotographs of Prussian blue iron-stained liver sections of the control (a) and tacrolimus-induced APR at 6 h (b), 12 h (c), 24 h (d), and 48 h (e) time points. Note iron deposition is dark blue in color (arrow), indicating the presence of iron in hepatocytes, sinusoidal spaces, and portal areas after the dose of tacrolimus in experimental groups as compared to the control.

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(b)

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