Metformin Reduces the Senescence of Renal Tubular Epithelial Cells in Diabetic Nephropathy via the MBNL1/miR-130a-3p/STAT3 Pathway

Figure 1

Metformin reduced HK-2 cell senescence that was induced by HG. (a–c) Western blot was used to determine the expression of P21 in HK-2 cells that were treated with NG, MA, and HG at different times. (d) The percentage of SA-β-gal-positive cells was detected in HK-2 cells that were exposed to NG, MA, and HG for 72 h. (e) P21 protein expression levels and (f) the percentage of SA-β-gal-positive cells were detected in HK-2 cells that were exposed to NG, NG+Met, HG, and HG+Met for 72 h. The data are expressed as the (). , vs. the NG group; , vs. HG group. Scale .

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