The Inhibition of miR-873 Provides Therapeutic Benefit in a Lipopolysaccharide-Induced Neuroinflammatory Model of Parkinson’s Disease

Figure 3

The regulation of ABCA1 expression by miR-873 in U251 cells. The luciferase activity in the cells transfected with the plasmid expressing the ABCA1 3-untranslated region (3-UTR) reporter was inhibited following cotransfection of the miR-873 expression vector (b). The predicted binding sites of miR-873 in the 3-UTR of the human ABCA1 gene and the rodent Abca1 gene are shown (a). The mRNA (c) and protein (d) levels of ABCA1 were decreased following transfection with miR-873. The basal activity levels measured in the cells transfected with the empty vector were set to 1. The data are expressed as the ; , and compared with the respective controls.

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