Pharmacological Modulation of Cardiac Remodeling after Myocardial Infarction

Figure 1

The phases and the main pathological changes in post-MI cardiac remodeling. The early remodeling includes ischemia, cell death, and inflammation within hours to days after the acute myocardial insult. The late remodeling is characterized by ECM deposition and causes reactive cardiac hypertrophy, cardiac fibrosis, and ventricular dilatation.