Pharmacological Modulation of Cardiac Remodeling after Myocardial Infarction

Figure 3

MI-induced activation and pharmacologic inhibition of the renin-angiotensin-aldosterone system. Renin-angiotensin-aldosterone system regulates the functions of multiorgans. AMI causes a decrease in cardiac output, reduces tissue perfusion in the kidney and liver, and stimulates renin and angiotensinogen production. Consequently, angiotensin production is increased to stimulate ventricular remodeling. Meanwhile, aldosterone has similar effects on cardiac remodeling.