β-Lapachone Increases Survival of Septic Mice by Regulating Inflammatory and Oxidative Response

Figure 3

β-Lap pretreatment inhibits inflammatory cytokines and bacterial load but does not inhibit nitric oxide in the blood of septic animals. The concentrations of IL-1 β in the serum (a) and in peritoneal lavage (b) as well as TNF-α in the serum (c) and in peritoneal lavage (d) 24 h after CLP. Nitric oxide levels in serum (e) and in peritoneal lavage (f) 12 h and 24 h after CLP. Bacterial counts (CFUs) in blood (g) and in peritoneal lavage (h). vs. sham; ^# vs. CLP.

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