β-Lapachone Increases Survival of Septic Mice by Regulating Inflammatory and Oxidative Response

Figure 5

β-Lap posttreatment improves survival of severe septic mice and restores basal MDA and TEAC levels. (a) The survival rate of septic mice from saline, β-Lap (1 mg/kg/5 mg/kg), and ertapenem (30 mg/kg) groups. The MDA level rate of septic mice from saline (24 h post-CLP) and β-Lap (1 mg/kg), ertapenem (30 mg/kg) groups 7 days after surgery in the serum (b) and peritoneal lavage (c) TEAC levels of septic mice from saline (24 h post-CLP) and β-Lap (1 mg/kg), ertapenem (30 mg/kg) groups 7 days after surgery in the serum (d) and in peritoneal lavage (e) 7 days after surgery. vs. sham; ^# vs. CLP.

(a)

(b)

(c)

(d)

(e)