Olaquindox-Induced Liver Damage Involved the Crosstalk of Oxidative Stress and p53 In Vivo and In Vitro

Figure 1

OLA induced hepatic dysfunction, oxidative stress, and p53 activation in mice. C57BL/6 mice were orally administrated with OLA at the doses of 100, 200, and 400 mg/kg for 28 consecutive days. (a) ALT serum levels. (b) AST serum levels. (c) Effect of OLA on ultrastructure changes in mouse liver observed by electron microscope (1200x). (d–f) Impact of OLA treatment on SOD activity, MDA levels, and CAT activity. (g) p53 protein expressions in the liver tissue of mice were analyzed by western blotting. (h) The densitometry analysis of p53 by ImageJ 1.46 software. The results represent (). Compared with the control, , .

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