Olaquindox-Induced Liver Damage Involved the Crosstalk of Oxidative Stress and p53 In Vivo and In Vitro

Figure 3

p53 knockout decreased OLA-induced liver damage and oxidative stress in mice. (a) p53 protein expression was analyzed by western blotting in p53 wild type and p53 knockout groups. (b, c) Effect of p53 on OLA-induced ALT and AST serum levels. (d) Histopathological images of HE-stained liver sections from OLA-treated p53 wild type and p53 knockout mice. (e–g) Effect of p53 on OLA-induced MDA levels and CAT and SOD activities in mice. The results represent (). Compared with the p53 wt group, ; compared with the p53 wt+OLA group, ^#.

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