Ophiopogonin D Increases SERCA2a Interaction with Phospholamban by Promoting CYP2J3 Upregulation

Figure 11

The expression of CYP2J3 decreased after the PXR was knocked down. (a) OPD induces PXR nuclear translocation in H9c2 cells. , compared with the control group. (b) The expression of CYP2J3 decreased after the PXR was knocked down, , ^### versus the NC group. The effect of OPD on the transcription of the genes encoding CYP2J3 in HF H9c2 cells transfected with siPXR. ^a, ^d versus the si-control group. ^b, ^c versus the si-control group. ^e, ^f versus the si-control group. (c) The expression of CYP2J3 decreased after the PXR was knocked down. versus the control group, ^#, ^### versus the Helicid group. ^aP<0.05, ^bP<0.01 versus the control group. ^cP<0.05, ^dP<0.05, ^eP<0.05, ^f compared with the Helicid group. (d) The effect of OPD on the expression of CYP2J3 and PXR after PXR was knocked down in HF H9c2 cells. ^a, ^d versus the si-control group. ^b, ^c versus the si-control group. ^e, ^f versus the si-control group, per group.

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