Ophiopogonin D Increases SERCA2a Interaction with Phospholamban by Promoting CYP2J3 Upregulation

Figure 8

Effects of OPD on the phosphorylated status of PLB in different HF cardiomyocytes. (a) SERCA2a and p-PLB protein levels were decreased in AngII-induced HF cells, ^a,b versus the control group. The PLB expression increased compared with the control group, ^c. Different concentrations of OPD (0.1, 0.2, 0.5 μmol/L) reversed the change compared with the AngII-treated group, , ^{^}, ^#. (b) SERCA2a and p-PLB protein levels were decreased in ISO-induced HF cells, ^a,b versus the control group. The PLB expression increased compared with the control group, ^c. Different concentrations of OPD (0.25, 0.5, 1 μmol/L) reversed the change compared with the ISO-treated group, , ^{^}, ^#, per group.

(a)

(b)