What Is the Impact of Depletion of Immunoregulatory Genes on Wound Healing? A Systematic Review of Preclinical Evidence

Figure 3

Bias risk results and methodological quality indicators for all studies included in this systematic review that evaluated the effect of gene depletion on excisional and incisional wounds. Q1: Was the allocation sequence adequately generated and applied? Q2: Were the groups similar at baseline or were they adjusted for confounders in the analysis? Q3: Was the allocation to the different groups adequately concealed? Q4: Were the animals randomly housed during the experiment? Q5: Were the caregivers and/or investigators blinded from knowledge regarding which intervention each animal received during the experiment? Q6: Were animals selected at random for outcome assessment? Q7: Was the outcome assessor-blinded? Q8: Were incomplete outcome data adequately addressed? Q9: Are reports of the study free of selective outcome reporting? Q10: Was the study free of other problems that could result in a high bias risk? Q11: Was the number of animals per group and number of animals per cage presented? Q12: What conditions were the animals kept in? and Q13: Wound closure data were presented with follow-up days, photos, and graphs?