Research Article
Activation of the Melanocortin-1 Receptor by NDP-MSH Attenuates Oxidative Stress and Neuronal Apoptosis through PI3K/Akt/Nrf2 Pathway after Intracerebral Hemorrhage in Mice
Figure 7
The administration of LY294002 abolished the beneficial effects of NDP-MSH on oxidative stress and neuronal apoptosis. (a) The changes in the expression levels of MDA, CAT, and SOD in the perihematomal brain tissue after the administration of LY294002. Representative Western blot images (b) and quantitative analyses of p-AKT/AKT (c), p-Nrf2/Nrf2 (d), Bcl-2 (e), and cleaved caspase 3 (f). per group. # vs. sham; vs. ICH; @ vs. ICH + NDP-MSH + DMSO. LY294002: PI3K inhibitor.
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