The Poststroke Peripheral Immune Response Is Differentially Regulated by Leukemia Inhibitory Factor in Aged Male and Female Rodents

Figure 3

IL-1β, but not TNFα or IL-6, is affected by sex and treatment. (a) Among LIF-treated rats, aged females () had significantly lower levels of IL-1β compared to their PBS-treated counterparts (; ). However, there was no difference between the relative IL-1β expression between PBS-treated males () and LIF-treated males (). for both sham groups. However, (b) TNFα levels were not significantly altered among PBS-treated males (), LIF-treated males (), PBS-treated females (), and LIF-treated females (). for male sham and for female sham groups. (c) Furthermore, IL-6 levels were not significantly altered among PBS-treated males (), LIF-treated males (), PBS-treated females (), and LIF-treated females (). for both sham groups.

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