The Poststroke Peripheral Immune Response Is Differentially Regulated by Leukemia Inhibitory Factor in Aged Male and Female Rodents

Figure 5

Sex and treatment change levels of IFNγ and IFNγ-inducible inflammatory mediators. (a) There was no significant difference in IFNγ levels in the spleens of male or female rats after MCAO. per treatment group for all groups except sham groups (). (b) Relative levels of NO₂^- were significantly higher among MCAO+PBS females () compared to MCAO+PBS males (). LIF significantly decreased NO₂^- in the spleens of female rats () compared to the MCAO+PBS female rats (; ). There was no significant difference in relative NO₂^- levels between MCAO+LIF male rats () and MCAO+PBS male rats. for male sham and for female sham groups. (c) MCAO+LIF-treated female rats () had significantly higher levels of IL-3 in the spleen compared to MCAO+PBS females (; ) and MCAO+LIF males (; ). However, there were no differences between MCAO+PBS males () and MCAO+LIF males. for male sham group and for female sham group.

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