Resveratrol Mitigates Sevoflurane-Induced Neurotoxicity by the SIRT1-Dependent Regulation of BDNF Expression in Developing Mice

Figure 2

Effect of sevoflurane exposure on the expression of SIRT1 and BDNF in vivo and in vitro. (a, b) RT-PCR analysis of SIRT1 and BDNF mRNA expression between the control group and the sevoflurane group in hippocampal tissue, respectively ( per group). (c) Representative western blot bands of SIRT1 and BDNF in the neonatal mouse hippocampus ( per group). (d, e) Densitometry quantification of SIRT1 and BDNF expression ex vivo, respectively. (f) Representative western blot bands of SIRT1 and BDNF in primary hippocampal neurons ( per group). (g, h) Densitometry quantification of SIRT1 and BDNF expression in vitro, respectively. Data are shown as ( per group). , .

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