Resveratrol Mitigates Sevoflurane-Induced Neurotoxicity by the SIRT1-Dependent Regulation of BDNF Expression in Developing Mice

Figure 7

Motor function and spatial memory changes induced by sevoflurane exposure and pretreatment with resveratrol. (a) Total distance traveled by four groups of mice in the open field test. (b) The average speed traveled by four groups of mice in the open field test. (c) Representative swimming paths of the mice in the four experimental groups obtained from the training in quadrant 7 on P34. The mice were placed in the water facing the pool wall at the yellow point in quadrant 7 on the fourth day of training; the swimming path of mice was finished at the black point. Quadrant 6 is the target quadrant (marked by red lines), and platform ② is the target platform. (d) The escape latency in the MWM plotted against the training days. (e) The escape path length in the MWM plotted against the training days. (f) Analysis of the time spent in each quadrant during the probe trial of the MWM. (g) The platform crossing times during the probe trial of the MWM test. Data are shown as ( per group). , , control+DMSO vs. sevoflurane+DMSO; ^#, ^##, sevoflurane+resveratrol vs. sevoflurane+DMSO.

(a)

(b)

(c)

(d)

(e)

(f)

(g)