Histopathological sections of testicular tissue in sham-operated control, testicular ischemia-reperfusion, and sesamol-treated groups. Cross-sections of testicular tissue were stained using hematoxylin-eosin and evaluated microscopically at magnification ×200. (a) The histopathological examination revealed normal seminiferous tubular diameter, number of germ cell layers, and spermatogenesis from immature germ cells to mature spermatozoa in bilateral testes of the control group and contralateral testes of testicular ischemia-reperfusion and sesamol-treated groups. An open tubular lumen was observed at the center of the seminiferous tubule. (b) Abnormal testicular morphology with an atrophic seminiferous tubule (arrows), decreased number of germ cell layers (arrowheads), and maturation arrest of germ cells (arrowheads) was seen in ipsilateral testes of the testicular ischemia-reperfusion group. (c) The general appearance of ipsilateral testes in the sesamol-treated group was similar to the control group. However, sloughed germinal cells were present in the tubular lumen (arrow), which led to obstruction of the tubular lumen easily.