Salivary Antioxidants and Oxidative Stress in Psoriatic Patients: Can Salivary Total Oxidant Status and Oxidative Status Index Be a Plaque Psoriasis Biomarker?
Table 4
ROC analysis of antioxidant defence, total antioxidant/oxidant status, and markers of oxidative damage to proteins and lipids in nonstimulated saliva of psoriasis patients compared to the controls.
Parameter
NWS
AUC
95% confidence interval
value
Cut-off
Sensitivity
Specificity
Px (mU/mg protein)
0.65
0.53 to 0.7713
0.0204
>0.29
57.50
57.50
CAT (nmol H2O2/min/mg protein)
0.79
0.6861 to 0.8864
<0.0001
>0.47
72.50
72.50
SOD (mU/mg protein)
0.68
0.5634 to 0.8029
0.0048
>1.39
62.50
62.50
GSH (μg/mg protein)
0.78
0.6839 to 0.8823
<0.0001
<2.81
70.00
70.00
TAC (Trolox μmol/mg protein)
0.62
0.4949 to 0.7451
0.0647
>1.37
57.50
57.50
TOS (nmol H2O2/min/mg protein)
1.00
1 to 1
<0.0001
>45.26
100.00
100.00
OSI (TOS/TAC ratio)
1.00
1 to 1
<0.0001
>18.30
100.00
100.00
ROS production (nmol O2-/min/mg protein)
0.91
0.8501 to 0.9699
<0.0001
>6.55
80.00
80.00
AGE (AFU/mg protein)
0.95
0.902 to 0.9993
<0.0001
>1.69
90.00
90.00
AOPP (nmol/mg protein)
0.73
0.6174 to 0.8389
0.0004
>36.07
67.50
67.50
MDA (μmol/mg protein)
0.95
0.9028 to 1.002
<0.0001
>187.80
87.50
87.50
LOOH (nmol/mg protein)
0.72
0.5933 to 0.8367
0.0009
>534.00
67.50
67.50
Abbreviations: AGE: advanced glycation end products; AOPP: advanced oxidation protein products; AUC: area under curve; CAT: catalase; GSH: reduced glutathione; LOOH: total lipid hydroperoxides; MDA: malondialdehyde; NWS: nonstimulated whole saliva; OSI: oxidative stress index; ROS: reactive oxygen species; Px: peroxidase; SOD: superoxide dismutase; TAC: total antioxidant capacity; TOS: total oxidative status.
