Salivary Antioxidants and Oxidative Stress in Psoriatic Patients: Can Salivary Total Oxidant Status and Oxidative Status Index Be a Plaque Psoriasis Biomarker?
Table 5
ROC analysis of antioxidant defence, total antioxidant/oxidant status, and markers of oxidative damage to proteins and lipids in stimulated saliva of psoriasis patients compared to the controls.
Parameter
SWS
AUC
95% confidence interval
value
Cut-off
Sensitivity
Specificity
Px (mU/mg protein)
0.69
0.5784 to 0.8091
0.0029
>0.44
62.50
62.50
CAT (nmol H2O2/min/mg protein)
0.51
0.3854 to 0.6408
0.8399
<0.55
52.50
52.50
SOD (mU/mg protein)
0.87
0.7902 to 0.9523
<0.0001
>0.73
80.00
80.00
GSH (μg/mg protein)
0.67
0.5494 to 0.7881
0.0094
<2.32
62.50
62.50
TAC (Trolox μmol/mg protein)
0.94
0.8915 to 0.9848
<0.0001
>2.43
82.50
82.50
TOS (nmol H2O2/min/mg protein)
0.88
0.7955 to 0.957
<0.0001
>34.97
80.00
80.00
OSI (TOS/TAC ratio)
0.78
0.6823 to 0.8802
<0.0001
>15.38
70.00
70.00
ROS production (nmol O2-/min/mg protein)
0.96
0.9215 to 0.9973
<0.0001
>8.58
90.00
90.00
AGE (AFU/mg protein)
0.83
0.7444 to 0.9206
<0.0001
>1.92
75.00
75.00
AOPP (nmol/mg protein)
0.95
0.8996 to 0.9941
<0.0001
>21.37
85.00
85.00
MDA (μmol/mg protein)
0.67
0.5499 to 0.7863
0.0096
>461.50
62.50
62.50
LOOH (nmol/mg protein)
0.79
0.6829 to 0.8871
<0.0001
>714.70
70.00
70.00
Abbreviations: AGE: advanced glycation end products; AOPP: advanced oxidation protein products; AUC: area under curve; CAT: catalase; GSH: reduced glutathione; LOOH: total lipid hydroperoxides; MDA: malondialdehyde; OSI: oxidative stress index; ROS: reactive oxygen species; SWS: stimulated whole saliva; Px: peroxidase; SOD: superoxide dismutase; TAC: total antioxidant capacity; TOS: total oxidative status.
