Salivary Antioxidants and Oxidative Stress in Psoriatic Patients: Can Salivary Total Oxidant Status and Oxidative Status Index Be a Plaque Psoriasis Biomarker?
Table 6
ROC analysis of antioxidant defence, total antioxidant/oxidant status, and markers of oxidative damage to proteins and lipids in erythrocytes and plasma of psoriasis patients compared to the controls.
Parameter
AUC
95% confidence interval
value
Cut-off
Sensitivity
Specificity
Erythrocytes
GPx (mU/mg protein)
0.73
0.609 to 0.8472
0.0004
>0.55
65.00
65.00
CAT (nmol H2O2/min/mg protein)
0.85
0.7564 to 0.9336
<0.0001
>0.63
80.00
80.00
SOD (mU/mg protein)
0.51
0.3811 to 0.6414
0.8625
<6.29
57.00
57.00
Plasma
GSH (μg/mg protein)
0.82
0.7205 to 0.9108
<0.0001
<2.21
75.00
75.00
TAC (Trolox μmol/mg protein)
0.5
0.3618 to 0.6457
0.954
<3.56
52.50
52.50
OSI (TOS/TAC ratio)
0.96
0.916 to 0.9953
<0.0001
>8.81
85.00
85.00
AGE (AFU/mg protein)
0.92
0.8492 to 0.9895
<0.0001
>1.68
87.5
87.5
AOPP (nmol/mg protein)
0.77
0.6554 to 0.8746
<0.0001
>7.73
70.00
70.00
MDA (μmol/mg protein)
1.00
1 to 1
<0.0001
>264.00
100.00
100.00
LOOH (nmol/mg protein)
0.96
0.9091 to 1.013
<0.0001
>0.36
95.00
95.00
Abbreviations: AGE: advanced glycation end products; AOPP: advanced oxidation protein products; AUC: area under curve; CAT: catalase; GSH: reduced glutathione; GPx: glutathione peroxidase; LOOH: total lipid hydroperoxides; MDA: malondialdehyde; OSI: oxidative stress index; SOD: superoxide dismutase; TAC: total antioxidant capacity.
