Proanthocyanidins-Mediated Nrf2 Activation Ameliorates Glucocorticoid-Induced Oxidative Stress and Mitochondrial Dysfunction in Osteoblasts
PAC neutralized Dex-induced oxidative stress and mitochondrial dysfunction in osteoblasts. (a) Representative images showing the ROS level in the differentially treated osteoblasts. (b) Representative images showing MitoSox and JC-1 intensities in the differentially treated osteoblasts. (c) Representative images showing mitochondrial morphology in the differentially treated osteoblasts. (d–f) The activities of SOD, CAT, and GPx in Dex-treated cells with/without PAC. (g) The ATP levels in the differentially treated osteoblasts. The data in the figures represent the of 5 times in duplicates. versus the untreated group, ## versus the Dex group.