A Stereological Study of the Toxic Effects of Cerium Oxide during Pregnancy on Kidney Tissues in Neonatal NMRI Mice

Figure 1

Microscopic images of kidney tissue from 15-day-old mice. The 5 μm sections stained with Heidenhain’s Azan show histopathologic changes in the kidney tissue. Magnification: 400x (scale bars =100 μm). Control (a): renal tubules with a regular arrangement of epithelial cells and glomerulus with natural size components and structure (arrow: Bowman’s capsule membrane; star: Bowman’s capsule space). PT: proximal convoluted tubule; DT: distal convoluted tubule; G: glomerulus in the control group. Cerium oxide (CeO₂); 10 mg/kg body weight (bw) (b), CeO₂; 25 mg/kg bw (c): renal tubules with a regular arrangement of epithelial cells and glomeruli with natural size components and structure in the groups treated with 10 and 25 mg/kg bw CeO₂. CeO₂; 80 mg/kg bw (d): histological changes are not significant compared to the control group. CeO₂; 250 mg/kg bw (e): vacuolization in the renal tubules, along with disruption, injury, and degeneration in PTs, vascularization in the interstitial kidney tissue, hypertrophy in the glomerulus, and reduced Bowman’s capsule space in the 250 mg/kg bw CeO₂ treatment group.

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