Blood Oxidative Stress Marker Aberrations in Patients with Huntington’s Disease: A Meta-Analysis Study

Table 2

Summary of comparative outcomes for measurements of blood marker levels.

Marker	No. of studies	No. with HD/HC	Main effect		Heterogeneity				Publication bias
			Hedges g (95% CI)	value	statistic	df	value	statistic	Egger’s intercept	value
LPO	6	103/206	0.883 (0.637–1.130)	≤0.001	2.221	5	0.818	0	2.65081	0.10766
8-OHdG	3	52/65	1.727 (0.489–2.965)	0.006	17.520	2	<0.001	88.585	-0.65530	0.98446
GSH	3	52/95	-0.611 (-1.016–-0.207)	0.003	2.690	2	0.261	25.639	2.80380	0.84614
GPx	3	49/84	2.026 (0.570–3.482)	0.006	21.812	2	<0.001	90.831	15.55092	0.27934
SOD	3	49/84	-1.239 (-2.753–0.274)	0.109	28.130	2	<0.001	92.890	-15.59612	0.29130
Cholesterol	7	273/257	0.020 (-0.395–0.435)	0.925	24.093	6	0.001	75.097	-1.37103	0.44288
HDL	4	62/54	-0.435 (-0.898–0.028)	0.066	4.656	3	0.199	35.565	-2.99853	0.54086
LDL	3	44/44	-0.922 (-2.616–0.772)	0.286	24.681	2	<0.001	91.897	-7.49790	0.40826
Triglycerides	4	59/66	0.486 (-0.977–1.949)	0.515	40.437	3	<0.001	92.581	12.84671	0.11963

df: degrees of freedom; HD: Huntington’s disease; LPO: lipid peroxidation products; 8-OHdG: 8-hydroxyguanosine; GSH: glutathione; GPx: glutathione peroxidase; SOD: superoxide dismutase; LDL: low-density lipoprotein; HDL: high-density lipoprotein.