Ticagrelor Conditioning Effects Are Not Additive to Cardioprotection Induced by Direct NLRP3 Inflammasome Inhibition: Role of RISK, NLRP3, and Redox Cascades

<div>Schematic representation of rat treatments <i>in vivo</i> and various protocols <i>ex vivo</i>. Rats received water or Ticagrelor (TIC) by oral gavage for 3 days; then, hearts were isolated and perfused. After stabilization, isolated hearts were submitted to specific treatment and then to global ischemia/reperfusion protocol.</div>

Oxidative Medicine and Cellular Longevity

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Figure 1: Ticagrelor Conditioning Effects Are Not Additive to Cardioprotection Induced by Direct NLRP3 Inflammasome Inhibition: Role of RISK, NLRP3, and Redox Cascades 

Figure 1 | Ticagrelor Conditioning Effects Are Not Additive to Cardioprotection Induced by Direct NLRP3 Inflammasome Inhibition: Role of RISK, NLRP3, and Redox Cascades 