Potential Protective and Therapeutic Roles of the Nrf2 Pathway in Ocular Diseases: An Update

Table 2

Nrf2 regulative function of noncoding RNAs.

Name of miRNAs	Experimental subjects	Functions and mechanisms
miR-4532	Human lens epithelial cells	Inhibition of miR-4532 protects HLECs from UVR-induced oxidative injury via activation of the SIRT6-Nrf2 pathway [96]
miR-27a	TMCs	Regulates Nrf2 expression at the posttranscriptional level [181]
miR-29b	Tenon’s capsule fibroblast	TGF-β2 fibroblast proliferation via suppression of miR-29b expression regulated by Nrf2 [117]
miR-93	TMCs	Inhibits viability and inducing apoptosis of the GTM cells by the suppression of Nrf2 [97, 182]
miR-141	RGCs	Attenuates UV-induced oxidative stress via activating Keap1-Nrf2 signaling [183]
miR-144	RPEs	Inhibiting microRNA-144 potentiates Nrf2-dependent antioxidant signaling and protects against OS-induced outer retinal degeneration [184]
miR-626	RPEs	Ectopic overexpression of miR-626 targeting the 3-UTR (3-untranslated region) of Keap1 downregulates its expression, promoting Nrf2 protein stabilization and nuclear translocation, leading to the expression of HO-1, NOQ1, and GCLC [185]
miR-601	RPEs	Overexpression of miR-601 inhibits Cul3 3-UTR activity and downregulates Cul3 expression, leading to Nrf2 protein stabilization and its nuclear translocation as well as expression of HO-1, NQO1, and GCLC [186]
lncRNA-MEG3	Tenon’s capsule fibroblast	The functional interaction between lncRNA-MEG3 and Nrf2 constitutes the mechanism by which TGF-β2 induces Tenon’s capsule fibroblast proliferation after glaucoma filtration surgery via the direct binding of MEG3 to Nrf2 [187]
lncRNA-Sox2OT	RGCs	Sox2OT knockdown plays an antioxidative role via regulating Nrf2/HO-1 signaling activity [188]