MicroRNA-874-3p Aggravates Doxorubicin-Induced Renal Podocyte Injury via Targeting Methionine Sulfoxide Reductase B3

Figure 2

Dox aggravates oxidative damage and apoptosis in vitro and in vivo. (a) Intracellular ROS levels in human podocytes and mouse primary podocytes (). (b) The levels of MDA, SOD, GSH, and GSH-Px in kidney tissues of mice (). (c) Cell apoptosis based on TUNEL assay in vitro and in vivo. (d) The protein levels of WT-1, nephrin, and desmin in kidney tissues of mice by western blotting assay (). Values are listed as the . and compared with control groups.

(a)

(b)

(c)

(d)