MicroRNA-874-3p Aggravates Doxorubicin-Induced Renal Podocyte Injury via Targeting Methionine Sulfoxide Reductase B3

<div>miR-874-3p mitigates Dox-induced renal podocyte injury via adjusting MsrB3 signal after antagomir test in mice. (a) The expression levels of WT-1, nephrin, and desmin after blockade of miR-874-3p by western blotting assay. (b) The expression levels of miR-874-3p and MsrB3 by real-time PCR assay in the kidney of mice after treatment with miR-874-3p antagomir. (c) The protein level of MsrB3 after treatment with miR-874-3p antagomir based on western blotting assay. (d) The protein levels of SOD2, NQO1, Bax, and Bcl-2 after administration with miR-874-3p antagomir <i>in vivo</i>. 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Oxidative Medicine and Cellular Longevity

fig8

Figure 8

Figure 8: MicroRNA-874-3p Aggravates Doxorubicin-Induced Renal Podocyte Injury via Targeting Methionine Sulfoxide Reductase B3 