MicroRNA-874-3p Aggravates Doxorubicin-Induced Renal Podocyte Injury via Targeting Methionine Sulfoxide Reductase B3

<div>Blockade of MsrB3 aggravates Dox-caused injury <i>in vitro</i>. (a) Intracellular ROS level in podocytes after transfection with MsrB3 siRNA. (b) Cell apoptosis after transfection of MsrB3 siRNA. (c) The expression level of MsrB3 after transfection with MsrB3 siRNA in human podocytes based on real-time PCR assay. (d) The protein level of MsrB3 after transfection of MsrB3 siRNA by western blotting assay in human podocytes. (e) The protein levels of SOD2, NQO1, Bax, and Bcl-2 after transfection of MsrB3 siRNA in human podocytes. 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Oxidative Medicine and Cellular Longevity

fig9

Figure 9

Figure 9: MicroRNA-874-3p Aggravates Doxorubicin-Induced Renal Podocyte Injury via Targeting Methionine Sulfoxide Reductase B3 