Review Article
Reactive Astrogliosis: Implications in Spinal Cord Injury Progression and Therapy
Table 3
Positive and negative influence of reactive astrogliosis.
| Positive effects | References | Limits leukocyte infiltration, repairs the blood–brain barrier | [122, 125–127] | Uptakes excess glutamate and prevents chronic glutamate neurotoxicity | [124, 128] | Promotes neuronal survival as well as axonal regeneration | [28, 129, 130] | Alleviates neurodegenerative disease | [131, 132] | Maintains the brain’s excitation/inhibition balance, prevents the development of epileptic seizures | [133] |
| Negative effects | References | Limits axonal regeneration and functional recovery after SCI | [112, 134–136] | Contributes to the development and persistence of chronic pain | [137, 138] | Inhibits differentiation of oligodendrocyte precursor cells | [117–120] | Fosters brain metastases via STAT3 signaling | [139] |
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