Metformin Promotes Axon Regeneration after Spinal Cord Injury through Inhibiting Oxidative Stress and Stabilizing Microtubule

Figure 4

Metformin promoted neurite repair by activating the PI3K/Akt signaling pathway in acute SCI. (a) Representative western blots of Ace-tubulin, Tyr-tubulin, and MAP2 in each group. (b–d) Quantification of western blots data from (a). ; and vs. the indicated group. (e) Coimmunofluorescence images show Ace-tubulin (green) and GFAP (red) at 14 d after SCI in each group. . (f) Quantification of distance of axon across border. ; and vs. the indicated group.

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