Metformin Promotes Axon Regeneration after Spinal Cord Injury through Inhibiting Oxidative Stress and Stabilizing Microtubule

Figure 9

Metformin plays a protective role in mitochondrial function in vitro. (a) PC12 cells incubated with JC-1 represented the mitochondrial membrane potential in each group. . (b) Quantification of aggregate/monomer fluorescence ratio from (a). and vs. the indicated group. (c) The fluorescence images of the DCFH-DA probe for hydrogen peroxide of PC12 in each group. . (d) Quantification of fluorescence density from (c). , , and vs. the indicated group. (e) The levels of total ATP in each group. and vs. the indicated group.

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