LCZ696 Ameliorates Oxidative Stress and Pressure Overload-Induced Pathological Cardiac Remodeling by Regulating the Sirt3/MnSOD Pathway
LCZ696 treatment mitigated TAC-induced pathological cardiac hypertrophy. (a) Representative cross-sectional HE staining images and WGA staining images for the sham or TAC mouse hearts treated with vehicle or LCZ696 for 4 weeks. (b) Statistics analysis of cross-sectional areas of cardiomyocytes based on HE staining ( cells per group). (c) mRNA levels of ANP and BNP in different treatment groups. mRNA levels are normalized to the GAPDH mRNA level and converted to fold change relative to the sham+vehicle group ( mice per group). Data are presented as . vs. the sham+vehicle group, # vs. the TAC+vehicle group. ANP: atrial natriuretic peptide; BNP: brain natriuretic peptide; WGA: wheat germ agglutinin; β-MHC: myosin heavy chain β.