Genetic Polymorphism of the Nrf2 Promoter Region (rs35652124) Is Associated with the Risk of Diabetic Foot Ulcers
Table 2
Distribution of allele and genotype frequencies and genetic interrelation of rs35652124 SNP with T2DM and DFU: odds ratio (OR) for minor alleles and their homozygous and heterozygous genotypes.
rs35652124
Genotypes
Alleles
CC
CT
TT
C
T
NGT
27 (18%)
105(70%)
18 (12%)
159(53%)
141 (47%)
T2DM
22(14.7%)
93(62%)
35(23.3%)
137(46%)
163 (54%)
DFU
8(8%)
40(40%)
52(52%)
56(28%)
144(72%)
NGT vs. T2DM OR (95% CI)
0.8 (0.4-1.4)
0.7 (0.4-1.1)
2.2 (1.2-4.2)
0.5 (0.3-0.7)
1.3 (1-1.8)
NGT vs. DFU OR (95% CI)
0.4 (0.2-0.9)
0.3 (0.2-0.5)
7.9 (4-14.9)
0.3 (0.2-0.5)
2.9 (2-4.3)
T2DM vs. DFU OR (95% CI)
0.5 (0.2-1.2)
0.4 (0.2-0.7)
4 (2.1-6.1)
0.5 (0.3-0.7)
2.2 (1.5-3.2)
Figures in bold are significant with and has odds ratio greater than one, suggesting the pathogenicity.
