Oxidative Medicine and Cellular Longevity / 2020 / Article / Tab 3

Research Article

Chloroquine Improves Deoxynivalenol-Induced Inflammatory Response and Intestinal Mucosal Damage in Piglets

Table 3

Effect of dietary RAPA and CQ on serum inflammatory cytokine level following exposure to DON.

ParametersCONDONRAPA+DONCQ+DONSEM value

IL-6 (pg/mL)553.07c652.04b718.29a592.32c15.93<0.01
IL-8 (pg/mL)34.32b33.42b43.88a31.76b1.31<0.01
IL-12 (pg/mL)36.03c46.10ab52.35a37.85bc1.89<0.01
IL-1β (pg/mL)366.27ab431.12a381.23ab314.97b13.780.02
TNF-α (pg/mL)102.34b124.08a131.36a111.92b4.540.05
TGF-β (pg/mL)441.70b336.34c632.91a421.70b28.73<0.01
IgG (g/L)1.471.631.471.560.050.37
IgM (g/L)0.43a0.53a0.14b0.48a0.03< 0.01

CON: saline solution; DON: deoxynivalenol diet and saline solution; RAPA+DON: rapamycin and deoxynivalenol diet; CQ+DON: chloroquine and deoxynivalenol diet. a,b,cValues within a row with different superscripts differ significantly (). If “ab” is in the marked place the measurement is neither significant compared to “a” or “b”, the same as other.

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