Chloroquine Improves Deoxynivalenol-Induced Inflammatory Response and Intestinal Mucosal Damage in Piglets

Table 3

Effect of dietary RAPA and CQ on serum inflammatory cytokine level following exposure to DON.

Parameters	CON	DON	RAPA+DON	CQ+DON	SEM	value
IL-6 (pg/mL)	553.07^c	652.04^b	718.29^a	592.32^c	15.93	<0.01
IL-8 (pg/mL)	34.32^b	33.42^b	43.88^a	31.76^b	1.31	<0.01
IL-12 (pg/mL)	36.03^c	46.10^ab	52.35^a	37.85^bc	1.89	<0.01
IL-1β (pg/mL)	366.27^ab	431.12^a	381.23^ab	314.97^b	13.78	0.02
TNF-α (pg/mL)	102.34^b	124.08^a	131.36^a	111.92^b	4.54	0.05
TGF-β (pg/mL)	441.70^b	336.34^c	632.91^a	421.70^b	28.73	<0.01
IgG (g/L)	1.47	1.63	1.47	1.56	0.05	0.37
IgM (g/L)	0.43^a	0.53^a	0.14^b	0.48^a	0.03	< 0.01

CON: saline solution; DON: deoxynivalenol diet and saline solution; RAPA+DON: rapamycin and deoxynivalenol diet; CQ+DON: chloroquine and deoxynivalenol diet. ^a,b,cValues within a row with different superscripts differ significantly (). If “ab” is in the marked place the measurement is neither significant compared to “a” or “b”, the same as other.