Oxidative Medicine and Cellular Longevity / 2020 / Article / Tab 5

Research Article

Chloroquine Improves Deoxynivalenol-Induced Inflammatory Response and Intestinal Mucosal Damage in Piglets

Table 5

Effect of dietary RAPA and CQ on intestinal morphology following exposure to DON.

ParametersCONDONRAPA+DONCQ+DONSEM value

Jejunum
 Villus height (μm)352.63a323.54b259.51c341.10a19.93<0.01
 Crypt depth (μm)86.70b97.31a78.21c90.20b3.46<0.01
 Villus height: crypt4.07a3.33c3.32c3.79b0.09<0.01
 Wall thickness (μm)159.24bc182.40a150.12c166.48b4.72<0.01
 Goblet cell number8.509.178.177.670.140.32
 Lymphocyte number31.50a30.00a27.83b30.67a0.10<0.01
Ileum
 Villus height (μm)325.30a267.71c223.00d297.78b20.14<0.01
 Crypt depth (μm)89.19a88.27a77.80b87.54a2.81<0.01
 Villus height: crypt3.65a3.16b2.87c3.42a0.14<0.01
 Wall thickness (μm)160.20a168.36a94.80 b159.06a17.59<0.01
 Goblet cell number10.179.3310.6711.670.290.29
 Lymphocyte number31.5029.6730.5029.330.100.25

CON: saline solution; DON: deoxynivalenol diet and saline solution; RAPA+DON: rapamycin and deoxynivalenol diet; CQ+DON: chloroquine and deoxynivalenol diet. a,b,cValues within a row with different superscripts differ significantly (). If “ab” is in the marked place the measurement is neither significant compared to “a” or “b”, the same of other.

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