Nrf2 Inhibitor, Brusatol in Combination with Trastuzumab Exerts Synergistic Antitumor Activity in HER2-Positive Cancers by Inhibiting Nrf2/HO-1 and HER2-AKT/ERK1/2 Pathways
Trastuzumab plus brusatol potently inhibited the activation of Nrf2/HO-1 and HER2-AKT/ERK1/2 pathways. (a, b) BT-474 and SK-OV-3 cells were treated with trastuzumab or brusatol alone, or their combination for 24 hours. The changes in Nrf2/HO-1 and HER2-AKT/ERK1/2 signaling pathways were monitored by western blotting. (c, d) Densitometric analysis was performed on the western blotting. The levels of Nrf2, HO-1, p-HER2, p-AKT, and p-ERK1/2 were quantified by using the software Image J. The data are expressed as the of three independent experiments. ,,.
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