Nrf2 Inhibitor, Brusatol in Combination with Trastuzumab Exerts Synergistic Antitumor Activity in HER2-Positive Cancers by Inhibiting Nrf2/HO-1 and HER2-AKT/ERK1/2 Pathways

<div>Combinatorial treatment with trastuzumab plus brusatol regressed Nrf2/HO-1 and HER2-AKT/ERK1/2 signaling pathways in SK-OV-3 tumor xenografts. (a) Tumors removed from SK-OV-3 xenografts upon treatment with control IgG (15 mg/kg), trastuzumab (15 mg/kg), brusatol (2 mg/kg), or trastuzumab (15 mg/kg) plus brusatol (2 mg/kg) were then subjected to Western blotting to detect the change of a series of proteins involved in Nrf2/HO-1 and HER2-AKT/ERK1/2 pathways. Two representative samples from each treatment group were shown here. (b) Quantification of Western blotting signal intensity analysis is expressed relative to the <i>β</i>-actin loading control by using Image J software. 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Oxidative Medicine and Cellular Longevity

fig8

Figure 8

Figure 8: Nrf2 Inhibitor, Brusatol in Combination with Trastuzumab Exerts Synergistic Antitumor Activity in HER2-Positive Cancers by Inhibiting Nrf2/HO-1 and HER2-AKT/ERK1/2 Pathways 

Figure 8 | Nrf2 Inhibitor, Brusatol in Combination with Trastuzumab Exerts Synergistic Antitumor Activity in HER2-Positive Cancers by Inhibiting Nrf2/HO-1 and HER2-AKT/ERK1/2 Pathways 