Irisin Rescues Blood-Brain Barrier Permeability following Traumatic Brain Injury and Contributes to the Neuroprotection of Exercise in Traumatic Brain Injury

Figure 1

CSF irisin levels were increased and positively correlated with the recovery in patients with TBI. (a) The serum level of irisin was derived from patients who suffered from TBI for 2 days or 7 days. (b) The CSF level of irisin was derived from patients who suffered from TBI for 2 days or 7 days. (c) Correlations between CSF irisin levels and serum irisin levels in patients who suffered from TBI for 2 days. (d) Correlations between CSF irisin levels and serum irisin levels in patients who suffered from TBI for 7 days. (e) Correlations between GCS and CSF irisin levels in patients who suffered from TBI for 2 days. (f) Correlations between GCS and CSF irisin levels in patients who suffered from TBI for 7 days. . The significance of correlations was evaluated by determining Spearman’s rank correlation coefficients. vs. TBI for 2 days.

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