Irisin Rescues Blood-Brain Barrier Permeability following Traumatic Brain Injury and Contributes to the Neuroprotection of Exercise in Traumatic Brain Injury

Figure 10

Genetic ablation of UCP2 compromised the protective effect of exogenous irisin on BBB integrity at 24 hours after TBI in mice. (a, c) Evans blue extravasation in WT and UCP2^−/− mice at 24 hours after TBI. (b) Evaluation of brain water content in WT and UCP2^−/− mice at 24 hours after TBI. Data are expressed as the . Scale bars: 20 μm. . Significance was determined by one-way ANOVA and Dunnett’s post hoc analysis. versus WT mice under the same conditions; ^# versus TBI group in WT mice; ^& versus Sham group in WT mice.

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